原创力文档a novel microrna and transcription factor mediated regulatory network in schizophrenia一种新颖的微rna在精神分裂症和转录因子介导的监管网络.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a novel microrna and transcription factor mediated regulatory network in schizophrenia一种新颖的微rna在精神分裂症和转录因子介导的监管网络
Guo et al. BMC Systems Biology 2010, 4:10
/1752-0509/4/10
RESEARCH ARTICLE Open Access
A Novel microRNA and transcription factor
mediated regulatory network in schizophrenia
1 1,2 1,2 1,2,3*
An-Yuan Guo , Jingchun Sun , Peilin Jia , Zhongming Zhao
Abstract
Background: Schizophrenia is a complex brain disorder with molecular mechanisms that have yet to be
elucidated. Previous studies have suggested that changes in gene expression may play an important role in the
etiology of schizophrenia, and that microRNAs (miRNAs) and transcription factors (TFs) are primary regulators of
this gene expression. So far, several miRNA-TF mediated regulatory modules have been verified. We hypothesized
that miRNAs and TFs might play combinatory regulatory roles for schizophrenia genes and, thus, explored miRNA-
TF regulatory networks in schizophrenia.
Results: We identified 32 feed-forward loops (FFLs) among our compiled schizophrenia-related miRNAs, TFs and
genes. Our evaluation revealed that these observed FFLs were significantly enriched in schizophrenia genes. By
converging the FFLs and mutual feedback loops, we constructed a novel miRNA-TF regulatory network for
schizophrenia. Our analysis revealed EGR3 and hsa-miR-195 were core regulators in this regulatory network. We
next proposed a model highlighting EGR3 and miRNAs involved in signaling pathways and regulatory networks in
the nervous system. Finally, we suggested several single nucleotide polymorphisms (SNPs) located on miRNAs, their
target sites, and TFBSs, which may have an effect in schizophrenia gene regulation.
Conclusions: This study provides many insights on the regulatory mechanisms of genes involved in schizophrenia.
It represents the first investigation of a miRNA-TF regulatory networ
您可能关注的文档
- a new concept for cancer therapy out-competing the aggressor癌症治疗的一个新概念体型侵略者.pdf
- a new cultivation method for microbial oil production cell pelletization and lipid accumulation by mucor circinelloides一种新的培养方法微生物石油生产电池粒化和脂质积累的毛霉菌circinelloides.pdf
- a new essential protein discovery method based on the integration of protein-protein interaction and gene expression data一种新的重要蛋白质的发现方法基于蛋白质相互作用和基因表达数据的集成.pdf
- a new early cretaceous relative of gnetales siphonospermum simplex gen. et sp. nov. from the yixian formation of northeast china新一白垩纪早期相对买麻藤目siphonospermum单工将军等sp. 11月从中国东北的古生物学家.pdf
- a new classification of the long-horned caddisflies (trichoptera leptoceridae) based on molecular data长角石蛾的一种新的分类(trichoptera leptoceridae)基于分子数据.pdf
- a new dynamical layout algorithm for complex biochemical reaction networks一种新的动态布局算法对于复杂的生化反应网络.pdf
- a new efficient trial design for assessing reliability of ankle-brachial index measures by three different observer groups一个新的有效的评估的可靠性试验设计踝肱指数由三个不同的观察者的措施.pdf
- a new device for measurement of fibrin clot lysis application to the euglobulin clot lysis time新设备的测量纤维蛋白凝块溶解程序凝优球蛋白溶解时间.pdf
- a new experimental approach for studying bacterial genomic island evolution identifies island genes with bacterial host-specific expression patterns一种新的实验方法研究细菌的基因组岛进化识别岛与细菌的寄主专一性的基因表达模式.pdf
- a new analysis tool for individual-level allele frequency for genomic studies一个新的分析工具对个人层面基因组研究等位基因频率.pdf
- a novel method to quantify local cpg methylation density by regional methylation elongation assay on microarray一个新颖的方法来量化本地cpg甲基化区域甲基化延伸分析微阵列密度.pdf
- a novel model-based approach for dose determination of glycopyrronium bromide in copd一种新颖的基于模型的方法剂量测定格隆溴铵在慢性阻塞性肺病.pdf
- a novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous spink1 mutations一种新型钙敏感受体基因的突变与慢性胰腺炎与杂合的家庭spink1突变体内.pdf
- a novel method, digital genome scanning detects kras gene amplification in gastric cancers involvement of overexpressed wild-type kras in downstream signaling and cancer cell growth一个新颖的方法,数字在胃癌症基因组扫描检测kras基因扩增过表达野生型kras参与下游信号和癌症细胞生长.pdf
- a novel mutation in the tyrosine kinase domain of erbb2 in hepatocellular carcinoma酪氨酸激酶域的一种新的突变erbb2在肝细胞癌.pdf
- a novel pcr-based method for high throughput prokaryotic expression of antimicrobial peptide genes一种新型pcr进行高通量方法抗菌肽基因的原核表达.pdf
- a novel real-time ultrasonic method for prion protein detection using plasminogen as a capture molecule朊蛋白一种新型实时超声方法检测使用纤溶酶原作为捕获物分子.pdf
- a novel role for microglia in minimizing excitotoxicity一个新颖的减少会引起小胶质细胞的作用.pdf
- a novel multifunctional oligonucleotide microarray for toxoplasma gondii一种新型多功能寡核苷酸微阵列刚地弓形虫.pdf
- a novel scoring system for prognostic prediction in d-galactosaminelipopolysaccharide-induced fulminant hepatic failure balbc mice一种新的评分系统在d-galactosaminelipopolysaccharide-induced暴发性肝衰竭预后预测balbc老鼠.pdf
文档评论（0）