a novel mutation in the tyrosine kinase domain of erbb2 in hepatocellular carcinoma酪氨酸激酶域的一种新的突变erbb2在肝细胞癌.pdfVIP

BMC Cancer BioMed Central Research article Open Access A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma 1,2 4 4 Tanios Bekaii-Saab* , Nita Williams , Christoph Plass , Miguel Villalona Calero1,2 and Charis Eng3,4,5 Address: 1Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA, 2Department of Pharmacology, The Ohio State University, Columbus, Ohio, USA, 3Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA, 4Department of Molecular Virology, Immunology and Medical Genetics; Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA and 5Genomic Medicine Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA Email: Tanios Bekaii-Saab* - Tanios.Bekaii-Saab@; Nita Williams - Nita.Williams@; Christoph Plass - Christoph.Plass@; Miguel Villalona Calero - Miguel.Villalona@; Charis Eng - engc@ * Corresponding author Published: 06 December 2006 Received: 24 August 2006 Accepted: 06 December 2006 BMC Cancer 2006, 6:278 doi:10.1186/1471-2407-6-278 This article is available from: /1471-2407/6/278 © 2006 Bekaii-Saab et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, di