原创力文档a probabilistic framework to predict protein function from interaction data integrated with semantic knowledge从交互数据概率框架来预测蛋白质功能与语义知识集成.pdfVIP
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a probabilistic framework to predict protein function from interaction data integrated with semantic knowledge从交互数据概率框架来预测蛋白质功能与语义知识集成
BMC Bioinformatics BioMed Central
Methodology article Open Access
A probabilistic framework to predict protein function from
interaction data integrated with semantic knowledge
1 1 2 1
Young-Rae Cho* , Lei Shi , Murali Ramanathan and Aidong Zhang
Address: 1Department of Computer Science and Engineering, State University of New York, Buffalo, NY, USA and 2Department of Pharmaceutical
Sciences, State University of New York, Buffalo, NY, USA
Email: Young-Rae Cho* - ycho8@; Lei Shi - lshi2@; Murali Ramanathan - murali@;
Aidong Zhang - azhang@
* Corresponding author
Published: 18 September 2008 Received: 8 April 2008
Accepted: 18 September 2008
BMC Bioinformatics 2008, 9:382 doi:10.1186/1471-2105-9-382
This article is available from: /1471-2105/9/382
© 2008 Cho et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: The functional characterization of newly discovered proteins has been a challenge
in the post-genomic era. Protein-protein interactions provide insights into the functional analysis
because the function of unknown proteins can be postulated on the basis of their interaction
evidence with known proteins. The protein
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