a randomized, double-blind, placebo-controlled trial to assess safety and tolerability during treatment of type 2 diabetes with usual diabetes therapy and either cycloset? or placebo一个随机、双盲、安慰剂对照试验来评估期间的安全性和耐受性与常规糖尿病治疗2型糖尿病的治疗和cycloset 或安慰剂.pdfVIP
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a randomized, double-blind, placebo-controlled trial to assess safety and tolerability during treatment of type 2 diabetes with usual diabetes therapy and either cycloset? or placebo一个随机、双盲、安慰剂对照试验来评估期间的安全性和耐受性与常规糖尿病治疗2型糖尿病的治疗和cycloset 或安慰剂
BMC Endocrine Disorders BioMed Central
Study protocol Open Access
A randomized, double-blind, placebo-controlled trial to assess
safety and tolerability during treatment of type 2 diabetes with
usual diabetes therapy and either Cycloset™ or placebo
1 2 3 1
Richard E Scranton* , J Michael Gaziano , Dean Rutty , Michael Ezrokhi
and Anthony Cincotta1
1 2
Address: Veroscience LLC, Tiverton RI, Harvard Medical School, Boston, USA, Division of Aging, Brigham Womens Hospital, Harvard Medical
School, Boston, USA and 3Everest Clinical Research Services Inc., Toronto, Canada
Email: Richard E Scranton* - richard_scranton@; J Michael Gaziano - jmgaziano@;
Dean Rutty - dean_rutty@; Michael Ezrokhi - michael_ezrokhi@;
Anthony Cincotta - anthony_cincotta@
* Corresponding author
Published: 25 June 2007 Received: 12 April 2007
Accepted: 25 June 2007
BMC Endocrine Disorders 2007, 7:3 doi:10.1186/1472-6823-7-3
This article is available from: /1472-6823/7/3
© 2007 Scranton et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Cycloset™ is a quick-release formulation of bromocriptine mesylate, a dopamine agonist, which in animal
models of insulin resi
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