adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase腺苷预处理减弱肝脏再灌注损伤大鼠通过阻止内皮一氧化氮合酶的下调.pdfVIP

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adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase腺苷预处理减弱肝脏再灌注损伤大鼠通过阻止内皮一氧化氮合酶的下调.pdf

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adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase腺苷预处理减弱肝脏再灌注损伤大鼠通过阻止内皮一氧化氮合酶的下调

BMC Gastroenterology BioMed Central BMC Gastroenterology x 2002, Open Access 2 Research article Adenosine preconditioning attenuates hepatic reperfusion injury in the rat by preventing the down-regulation of endothelial nitric oxide synthase Ferdinand Serracino-Inglott*, Ioannis T Virlos, Nagy A Habib, Robin CN Williamson and Robert T Mathie Address: Division of Surgery, Anaesthetics Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, UK E-mail: Ferdinand Serracino-Inglott* - fsinglott@; Ioannis T Virlos - itvirlos@; Nagy A Habib - nagy.habib@ic.ac.uk; Robin CN Williamson - r.williamson@ic.ac.uk; Robert T Mathie - rmathie@ *Corresponding author Published: 20 September 2002 Received: 23 April 2002 Accepted: 20 September 2002 BMC Gastroenterology 2002, 2:22 This article is available from: /1471-230X/2/22 © 2002 Serracino-Inglott et al; licensee BioMed Central Ltd. This article is published in Open Access: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. Keywords: ischemia, liver, Wistar rats, immunohistochemistry, NG-Nitro-L-arginine Abstract Background: Previous work has suggested that in the liver, adenosine preconditioning is mediated by nitric oxide. Whether the endothelial isoform of nitric oxide synthase plays a part in this mechanism has however not yet been investigated. Meth