analysis of epistatic interactions and fitness landscapes using a new geometric approach分析上位相互作用和健身景观使用新的几何方法.pdfVIP

BMC Evolutionary Biology BioMed Central Research article Open Access Analysis of epistatic interactions and fitness landscapes using a new geometric approach 1 2 2 3 Niko Beerenwinkel* , Lior Pachter , Bernd Sturmfels , Santiago F Elena and Richard E Lenski*4 Address: 1Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA, 2Department of Mathematics, University of California, Berkeley, CA 94720, USA, 3Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-UPV, 46022 València, Spain and 4Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA Email: Niko Beerenwinkel* - beerenw@; Lior Pachter - lpachter@; Bernd Sturmfels - bernd@; Santiago F Elena - sfelena@ibmcp.upv.es; Richard E Lenski* - lenski@ * Corresponding authors Published: 13 April 2007 Received: 17 October 2006 Accepted: 13 April 2007 BMC Evolutionary Biology 2007, 7:60 doi:10.1186/1471-2148-7-60 This article is available from: /1471-2148/7/60 © 2007 Beerenwinkel et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Understanding interactions between mutations and how they affect fitness