原创力文档antibacterial and dermal toxicological profiles of ethyl acetate extract from crassocephalum bauchiense (hutch.) milne-redh (asteraceae)乙酸乙酯提取物的抗菌和皮肤毒理学资料crassocephalum bauchiense(厨)。.pdfVIP
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antibacterial and dermal toxicological profiles of ethyl acetate extract from crassocephalum bauchiense (hutch.) milne-redh (asteraceae)乙酸乙酯提取物的抗菌和皮肤毒理学资料crassocephalum bauchiense(厨)。
Mouokeu et al. BMC Complementary and Alternative Medicine 2011, 11:43
/1472-6882/11/43
RESEARCH ARTICLE Open Access
Antibacterial and dermal toxicological profiles
of ethyl acetate extract from Crassocephalum
bauchiense (Hutch.) Milne-Redh (Asteraceae)
1 2 1 2 3
Raymond S Mouokeu , Rosalie AN Ngono , Paul K Lunga , Martin M Koanga , Alambert T Tiabou ,
Guy SS Njateng1, Jean DD Tamokou1 and Jules-Roger Kuiate1*
Abstract
Background: The emergence in recent years of numerous resistant strains of pathogenic bacteria to a range of
formerly efficient antibiotics constitutes a serious threat to public health. Crassocephalum bauchiense, a medicinal
herb found in the West Region of Cameroon is used to treat gastrointestinal infections as well as liver disorders.
The ethyl acetate extract from the leaves of C. bauchiense was evaluated for its antibacterial activity as well as
acute and sub-acute toxicities.
Methods: The plant extract was prepared by maceration in ethyl acetate. Its phytochemical screening was done
by standard methods. The broth microdilution method was used to evaluate the in vitro antibacterial activity. The
in vivo antibacterial activity of a gel formulation (0.05, 1 and 2% w/v) of this extract was evaluated using a
Staphylococcus aureus-induced dermatitis in a murine model. Selected haematological and biochemical parameters
were used to evaluate the dermal sub-acute toxicity of the extract in rats.
Results: Phytochemical screening of the C. bauchiense extract revealed the presence of alkaloids, phenols, tannins
and sterols. In vitro antibacterial activities were observed against all the tested microorganisms (MIC = 0.04-6.25
mg/ml). Formulated extract-gel (2% w/v) and gentamycin (reference dru
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