antibiotic resistance in primary care in austria - a systematic review of scientific and grey literature抗生素耐药性在初级保健在奥地利-科学和灰色文献的系统回顾.pdfVIP

Hoffmann et al. BMC Infectious Diseases 2011, 11:330 /1471-2334/11/330 RESEARCH ARTICLE Open Access Antibiotic resistance in primary care in Austria - a systematic review of scientific and grey literature 1* 1 2 1 Kathryn Hoffmann , Gernot Wagner , Petra Apfalter and Manfred Maier Abstract Background: Antibiotic resistance is an increasing challenge for health care services worldwide. While up to 90% of antibiotics are being prescribed in the outpatient sector recommendations for the treatment of community- acquired infections are usually based on resistance findings from hospitalized patients. In context of the EU-project called “APRES - the appropriateness of prescribing antibiotic in primary health care in Europe with respect to antibiotic resistance” it was our aim to gain detailed information about the resistance data from Austria in both the scientific and the grey literature. Methods: A systematic review was performed including scientific and grey literature published between 2000 and 2010. Inclusion and exclusion criteria were defined and the review process followed published recommendations. Results: Seventeen scientific articles and 23 grey literature documents could be found. In contrast to the grey literature, the scientific publications describe only a small part of the resistance situation in the primary health care sector in Austria. Merely half of these publications contain data from the ambulatory sector exclusively but these data are older than ten years, are very heterogeneous concerning the observed time period, the number and origin of the isolates and the kind of bacteria analysed. The grey literature yields more comprehensive and up-to- date information of the content of interest. These s