association between faecal load of lawsonia intracellularis and pathological findings of proliferative enteropathy in pigs with diarrhoea联系粪便堆lawsonia intracellularis和增生性肠病的病理发现猪腹泻.pdfVIP

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association between faecal load of lawsonia intracellularis and pathological findings of proliferative enteropathy in pigs with diarrhoea联系粪便堆lawsonia intracellularis和增生性肠病的病理发现猪腹泻.pdf

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association between faecal load of lawsonia intracellularis and pathological findings of proliferative enteropathy in pigs with diarrhoea联系粪便堆lawsonia intracellularis和增生性肠病的病理发现猪腹泻

Pedersen et al. BMC Veterinary Research 2012, 8:198 /1746-6148/8/198 RESEARCH ARTICLE Open Access Association between faecal load of lawsonia intracellularis and pathological findings of proliferative enteropathy in pigs with diarrhoea 1* 2 3 2 1 Ken Steen Pedersen , Marie Ståhl , Roberto Maurício Carvalho Guedes , Øystein Angen , Jens Peter Nielsen and Tim K Jensen2 Abstract Background: The study was designed to investigate correlation between histological findings of Lawsonia intracellularis in porcine cases of diarrhoea and the quantitative detection of Lawsonia intracellularis in faeces. A total of 156 pigs (10 to 70 days post weaning) with diarrhoea were randomly selected from 20 herds: The pigs were subjected to necropsy, histopathology, immunohistochemistry and faecal quantification of Lawsonia intracellularis by real time PCR. Results: The median Lawsonia intracellularis excretion was significantly higher in pigs with gross lesions of proliferative enteropathy (median excretion: 5.92 log10 bacteria/g faeces) compared to pigs without gross lesions of proliferative enteropathy (median excretion: 3.3 log10 bacteria/g faeces) (P0.001). Spearman’s correlation coefficient between the measureable PE lesions and L. intracellularis excretion was 0.50 (P0.001). A significantly increasing trend in Lawsonia intracellularis excretion level for increasing proliferative enteropathy histopathology and immunohistochemistry scores was demonstrated (P0.001; P0.001). Spearman’s correlation coefficient between the histopathology scores and L. intracellularis excretion was 0.67 (P0.001). Spearman’s correlation coefficient between the IHC scores and L. intracellularis excretion was 0.77 (P0.00