automated genome mining for natural products自动化的基因组开采天然产品.pdfVIP

BMC Bioinformatics BioMed Central Software Open Access Automated genome mining for natural products 1,2 1,2 1 Michael HT Li , Peter MU Ung , James Zajkowski , Sylvie Garneau- Tsodikova 1,2 and David H Sherman* 1,2,3 Address: 1Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA, 2Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA and 3Departments of Chemistry, and Microbiology Immunology, University of Michigan, Ann Arbor, MI, USA Email: Michael HT Li - mikeleez@; Peter MU Ung - pmung@; James Zajkowski - jamesez@; Sylvie Garneau- Tsodikova - sylviegt@; David H Sherman* - davidhs@ * Corresponding author Published: 16 June 2009 Received: 5 December 2008 Accepted: 16 June 2009 BMC Bioinformatics 2009, 10:185 doi:10.1186/1471-2105-10-185 This article is available from: /1471-2105/10/185 © 2009 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Discovery of new medicinal agents from natural sources has largely been an adventitious process based on screening of plant and microbial extracts combined with bioassay- guided identification and natural product structure elucidation. Increasingl