automatic reconstruction of a bacterial regulatory network using natural language processing细菌监管网络的自动重建使用自然语言处理.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Automatic reconstruction of a bacterial regulatory network using Natural Language Processing Carlos Rodríguez-Penagos*, Heladia Salgado, Irma Martínez-Flores and Julio Collado-Vides Address: Programa de Genómica Computacional, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Apdo. Postal 565- A, Avenida Universidad, Cuernavaca, Morelos, 62100, Mexico Email: Carlos Rodríguez-Penagos* - crodrigp@ccg.unam.mx; Heladia Salgado - heladia@ccg.unam.mx; Irma Martínez- Flores - imartflo@ccg.unam.mx; Julio Collado-Vides - collado@ccg.unam.mx * Corresponding author Published: 7 August 2007 Received: 12 January 2007 Accepted: 7 August 2007 BMC Bioinformatics 2007, 8:293 doi:10.1186/1471-2105-8-293 This article is available from: /1471-2105/8/293 © 2007 Rodríguez-Penagos et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Manual curation of biological databases, an expensive and labor-intensive process, is essential for high quality integrated data. In this paper we report the implementation of a state- of-the-art Natural Language Processing system that creates computer-readable networks of regulatory interactions directly from different collections of abstracts and full-text pap