histone tales echoes from the past, prospects for the future组蛋白的故事从过去的回声,未来的前景.pdfVIP

Murgatroyd and Spengler Genome Biology 2010, 11:105 /2010/11/2/105 R E S E A R C H H I G H L I G H T Histone tales: echoes from the past, prospects for the future Chris Murgatroyd and Dietmar Spengler* Abstract Although life history theory can offer detailed answers to the question of why phenotypes are different, it does Recent studies of the nematode dauer state provide not attempt to understand the mechanisms that mediate new insights into epigenetic processes that underlie and integrate these differences. ree recent studies [3-5] cellular memory. take us, however, an important step forward in this direction. ey build on the nematode Caenorhabditis elegans as a unique model system for studying animal It has been 150 years since Charles Darwin described in survival strategies and the environmental regulation of his seminal work On the Origin of Species how descent life histories. C. elegans is a rapidly growing worm and its with modification and natural selection could explain the entire life cycle, from an egg to an adult, takes only diversity of life. When Mendel’s theory of inheritance was 3.5 days in the presence of abundant food at 20°C. After rediscovered in the early 1900s and verified to be embryogenesis, C. elegans progresses through four larval consistent with natural selection, evolutionary biologists stages (L1 to L4) before becoming an