原创力文档hiv-1 drug resistance genotyping from antiretroviral therapy (art) na？ve and first-line treatment failures in djiboutian patientshiv - 1型耐药性从抗逆转录病毒疗法(art)na ve和吉患者的一线治疗失败.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
hiv-1 drug resistance genotyping from antiretroviral therapy (art) na？ve and first-line treatment failures in djiboutian patientshiv - 1型耐药性从抗逆转录病毒疗法(art)na ve和吉患者的一线治疗失败
Elmi Abar et al. Diagnostic Pathology 2012, 7:138
/content/7/1/138
RESEARCH Open Access
HIV-1 drug resistance genotyping from
antiretroviral therapy (ART) naïve and first-line
treatment failures in Djiboutian patients
1,2* 2 3 2 2
Aden Elmi Abar , Asma Jlizi , Houssein Youssouf Darar , Mohamed Ali Ben Hadj Kacem and Amine Slim
Abstract: In this study we report the prevalence of antiretroviral drug resistant HIV-1 genotypes of virus isolated
from Djiboutian patients who failed first-line antiretroviral therapy (ART) and from ART naïve patients.
Patients and methods: A total of 35 blood samples from 16 patients who showed first-line ART failure (1000 viral
genome copies/ml) and 19 ART-naïve patients were collected in Djibouti from October 2009 to December 2009.
Both the protease (PR) and reverse transcriptase (RT) genes were amplified and sequenced using National Agency
for AIDS Research (ANRS) protocols. The Stanford HIV database algorithm was used for interpretation of resistance
data and genotyping.
Results: Among the 16 patients with first-line ART failure, nine (56.2%) showed reverse transcriptase
inhibitor-resistant HIV-1 strains: two (12.5%) were resistant to nucleoside (NRTI), one (6.25%) to non-nucleoside
(NNRTI) reverse transcriptase inhibitors, and six (37.5%) to both. Analysis of the DNA sequencing data indicated that
the most common mutations conferring drug resistance were M184V (38%) for NRTI and K103N (25%) for NNRTI.
Only NRTI primary mutations K101Q, K103N and the PI minor mutation L10V were found in ART naïve individuals.
No protease inhibitor resistant strains were detected. In our study, we found no detectable resistance in 44% of
all pat
您可能关注的文档
- fabrication and characterisation of gaas gunn diode chips for applications at 77 ghz in automotive industry砷化镓耿氏二极管芯片制造和描述应用在汽车行业77 ghz.pdf
- fabrication and packaging of flexible polymeric microantennae for in vivo magnetic resonance imaging制造和包装柔性聚合物microantennae体内磁共振成像.pdf
- evaluation of an ambulatory system for the quantification of cough frequency in patients with chronic obstructive pulmonary disease量化评价的一个动态系统的慢性阻塞性肺疾病患者的咳嗽频率.pdf
- étude des bandes chromosomiques du porc et de trois différentes souches de rein de porc en culture (pk 15, f et rp)练习曲des杜·邦德chromosomiques猪肉等三人不同的souches de控制de猪肉在文化(pk 15 f et rp).pdf
- facile and convenient one-pot process for the synthesis of spirooxindole derivatives in high optical purity using (？)-(s)-brevicolline as an organocatalyst简单和方便锅法合成spirooxindole衍生产品光学纯度高使用()-(s)-brevicolline organocatalyst.pdf
- fabrication of unimolecular double-stranded dna microarrays on solid surfaces for probing dna-proteindrug interactions制造的单分子的双链dna微阵列探测固体表面dna-proteindrug交互.pdf
- factor xii mutations, estrogen-dependent inherited angioedema, and related conditions第十二因子突变,estrogen-dependent遗传性血管性水肿和相关条件.pdf
- fast calculation of the quartet distance between trees of arbitrary degrees快速计算任意度的四方树之间的距离.pdf
- fiber bragg grating sensor to monitor stress kinetics in drying process of commercial latex paints光纤布拉格光栅传感器监测应力动力学商业乳胶涂料的干燥过程.pdf
- fabrication and performance of mems-based pressure sensor packages using patterned ultra-thick photoresistsmems-based压力传感器的制作和性能包使用的超光阻.pdf
- hiv, appendectomy and postoperative complications at a reference hospital in northwest tanzania cross-sectional study参考医院的艾滋病,阑尾切除术,术后并发症在坦桑尼亚西北部的横断面研究.pdf
- hiv–1 dynamics a reappraisal of host and viral factors, as well as methodological issueshiv - 1动态宿主和病毒因素的重新评价,以及方法论的问题.pdf
- histological variants of cutaneous kaposi sarcoma皮肤卡波西肉瘤组织学变异.pdf
- hiv-1 prevalence and factors associated with infection in the conflict-affected region of north ugandahiv - 1感染患病率和相关因素受冲突影响地区的北乌干达.pdf
- hiv-1 integrase-dna recognition mechanismshiv - 1 integrase-dna识别机制.pdf
- hiv-1 entry, inhibitors, and resistancehiv - 1进入、抑制剂和阻力.pdf
- hiv-1 subtype c phylodynamics in the global epidemichiv - 1 c亚型phylodynamics全球流行病.pdf
- hiv-1 subtype distribution in morocco based on national sentinel surveillance data 2004-2005hiv - 1亚型分布在摩洛哥基于国家哨点监测数据2004 - 2005.pdf
- hiv-1 resistance conferred by sirna cosuppression of cxcr4 and ccr5 coreceptors by a bispecific lentiviral vector抗hiv - 1的sirna cosuppression授予由双特异性趋化因子受体cxcr4与ccr5 coreceptors慢病毒载体.pdf
- hiv-1 tat its dependence on host factors is crystal clearhiv - 1乙的依赖宿主因素是晶莹剔透.pdf
文档评论（0）