原创力文档multinational, observational study of procalcitonin in icu patients with pneumonia requiring mechanical ventilation a multicenter observational study跨国公司原降钙素的观察研究icu患者肺炎需要机械通气的多中心观察研究.pdfVIP
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multinational, observational study of procalcitonin in icu patients with pneumonia requiring mechanical ventilation a multicenter observational study跨国公司原降钙素的观察研究icu患者肺炎需要机械通气的多中心观察研究
Bloos et al. Critical Care 2011, 15:R88
/content/15/2/R88
RESEARCH Open Access
Multinational, observational study of
procalcitonin in ICU patients with pneumonia
requiring mechanical ventilation: a multicenter
observational study
1 2 3 4 5 6
Frank Bloos , John C Marshall , Richard P Dellinger , Jean-Louis Vincent , Guillermo Gutierrez , Emanuel Rivers ,
7 8 9 1* 1
Robert A Balk , Pierre-Francois Laterre , Derek C Angus , Konrad Reinhart , Frank M Brunkhorst
Abstract
Introduction: The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated
with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia.
Methods: This was a multicenter, observational study of critically ill adult patients with pneumonia requiring
mechanical ventilation conducted in 10 academic hospitals in Canada, the United States, and Central Europe. PCT
was measured daily for 14 days using an immuno-luminometric assay.
Results: We included 175 patients, 57 with community acquired pneumonia (CAP), 61 with ventilator associated
pneumonia (VAP) and 57 with hospital acquired pneumonia (HAP). Initial PCT levels were higher in CAP than VAP
patients (median (interquartile range: IQR); 2.4 (0.95 to 15.8) vs. 0.7 (0.3 to 2.15), ng/ml, P 0.001) but not
significantly different to HAP (2.2 (0.4 to 8.0) ng/ml). The 28-day ICU mortality rate for all patients was 18.3% with a
median ICU length of stay of 16 days (range 1 to 142 days). PCT levels were higher in non-survivors than in
survivors. Initial and maximum PCT levels correlated with
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