原创力文档molecular recognition and specific interactions for biosensing applications分子识别和生物传感的具体交互.pdfVIP
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molecular recognition and specific interactions for biosensing applications分子识别和生物传感的具体交互
Sensors 2008, 8, 6605-6641; DOI: 10.3390/s8106605
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Review
Molecular Recognition and Specific Interactions for Biosensing
Applications
Dong Chung Kim and Dae Joon Kang *
BK 21 Physics Research Division, Institute of Basic Science, SKKU Advanced Institute of
Nanotechnology, Center for Nanotubes and Nanostructured Composites, Sungkyunkwan University,
Suwon 440-746, Korea. E-Mail: kimdc@
* Author to whom correspondence should be addressed; E-Mail: djkang@; Tel.: +82-31-290-
5906; Fax: +82-31-290-5947
Received: 25 September 2008; in revised form: 16 October 2008 / Accepted: 20 October 2008 /
Published: 23 October 2008
Abstract: Molecular recognition and specific interactions are reliable and versatile routes
for site-specific and well-oriented immobilization of functional biomolecules on surfaces.
The control of surface properties via the molecular recognition and specific interactions at
the nanoscale is a key element for the nanofabrication of biosensors with high sensitivity
and specificity. This review intends to provide a comprehensive understanding of the
molecular recognition- and specific interaction-mediated biosensor fabrication routes that
leads to biosensors with well-ordered and controlled structures on both nanopatterned
surfaces and nanomaterials. Herein self-assembly of the biomolecules via the molecular
recognition and specific interactions on nanosc
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