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interferon-λ in hcv infection and therapy ？interferon-λ丙肝病毒感染和治疗
Viruses 2010, 2, 1589-1602; doi:10.3390/v2081589
OPEN ACCESS
viruses
ISSN 1999-4915
/journal/viruses
Review
Interferon- in HCV Infection and Therapy
Nicole E. Pagliaccetti and Michael D. Robek *
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA;
E-Mail: nicole.pagliaccetti@
* Author to whom correspondence should be addressed; E-Mail: michael.robek@;
Tel.: +1-203-785-6174; Fax: +1-203-785-6127.
Received: 28 June 2010 / Accepted: 28 July 2010 / Published: 5 August 2010
Abstract: Chronic infection with hepatitis C virus (HCV) is associated with significant liver
disease and is therefore an important public health problem. The current standard-of-care
therapy for chronic HCV infection consists of a combination of pegylated (PEG) interferon
(IFN)- and ribavirin. Although this therapy effectively generates a sustained viral response
in approximately half of treated individuals, it is associated with significant hematological
and neurological side effects. A new family of IFN-related proteins (IFN-1, 2, and 3; or
alternately, IL-29, 28A, 28B, respectively) possesses properties that may make these
cytokines superior to PEG-IFN- for HCV therapy. Genetic studies have also implicated
these proteins in both the natural and therapy-induced resolution of HCV infection. This
review summarizes the basic aspects of IFN- biology, the potential role of these cytokines
in HCV infection, and the outlook
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