nonrigid registration of brain tumor resection mr images based on joint saliency map and keypoint clustering非刚性的脑瘤切除登记先生基于联合显著地图和图像关键点集群.pdfVIP

Sensors 2009, 9, 10270-10290; doi:10.3390/ OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Nonrigid Registration of Brain Tumor Resection MR Images Based on Joint Saliency Map and Keypoint Clustering Zhijun Gu and Binjie Qin Department of Biomedical Engineering, School of Life Sciences Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; E-Mail: gzj0126@ Author to whom correspondence should be addressed; E-Mail: bjqin@; Tel.: +86-21-3420-4382. Received: 23 October 2009; in revised form: 1 December 2009 / Accepted: 9 December 2009 / Published: 17 December 2009 Abstract: This paper proposes a novel global-to-local nonrigid brain MR image registration to compensate for the brain shift and the unmatchable outliers caused by the tumor resection. The mutual information between the corresponding salient structures, which are enhanced by the joint saliency map (JSM), is maximized to achieve a global rigid registration of the two images. Being detected and clustered at the paired contiguous matching areas in the globally registered images, the paired pools of DoG keypoints in combination with the JSM provide a useful cluster-to-cluster correspondence to guide the local control-point correspondence detection and the outlier keypoint rejection. Lastly, a quasi-inverse consistent deformation is smoothly approximated to locally register brain images through the mapping the clustered control points by compact support radial basis functions. The 2D implementation of the method