new levels of sophistication in the transcriptional landscape of bacteria新层次的复杂的转录景观的细菌.pdfVIP

Minireview New levels of sophistication in the transcriptional landscape of bacteria Arnoud HM van Vliet* and Brendan W Wren† Addresses: *Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK. †Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Correspondence: Brendan W Wren. Email: brendan.wren@lshtm.ac.uk Bacterial regulatory RNAs are more than Abstract An extra layer of complexity in the regulation of gene expression intergenic junk in bacteria is now apparent through previously unanticipated As well as the familiar types of RNA - messenger RNA, roles of noncoding and antisense RNAs. ribosomal RNA, and transfer RNA - bacteria also express many other noncoding RNAs (Figure 1). Some of these are catalytic, such as RNase P, or interact directly with Bacteria are the great survivors on planet Earth, where proteins, like the 6S RNA that interacts directly with σ70- they can adapt and flourish in harsh environments ranging containing RNA polymerase [8] or the CsrA-sequestering from deep-sea vents to acidic mine shafts. A feature of CsrB and CsrC RNAs [9]. Most bacterial noncoding RNAs, many bacteria, particularly pathogenic bacteria, is their however, are thought to have roles in the post- ability to adapt and thrive in multiple environments, which transcriptional regulation of gene expression, using their provides them with a competitive advantage. For example, capacity for complementary base-p