原创力文档new insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus新见解巨噬细胞迁移抑制因子的作用和机制抗类固醇系统性红斑狼疮患者反应中.pdfVIP
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new insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus新见解巨噬细胞迁移抑制因子的作用和机制抗类固醇系统性红斑狼疮患者反应中
Wang et al. Arthritis Research Therapy 2012, 14:R103
/content/14/3/R103
RESEARCH ARTICLE Open Access
New insights into the role and mechanism of
macrophage migration inhibitory factor in
steroid-resistant patients with systemic lupus
erythematosus
1† 2† 1 1 3 1 1
Fang-Fang Wang , Li-An Zhu , Yu-Qiong Zou , Hui Zheng , Alisa Wilson , Cheng-De Yang , Nan Shen ,
3 3 1 1*
Daniel J Wallace , Michael H Weisman , Shun-Le Chen and Liang-Jing Lu
Abstract
Introduction: Glucocorticoid (GC) therapy remains important in improving the prognosis of patients with systemic
lupus erythematosus (SLE). However, some patients do not achieve an effective response with GC treatment,
creating an obstacle to the remission of SLE. Identification of the underlying mechanisms responsible for steroid
resistance can be significant. Macrophage migration inhibitory factor (MIF) arouses our interest because of its
reciprocal relationship with GCs. In the present study, we investigated for the first time whether MIF correlated
with steroid resistance in SLE and explored potential mechanisms of action.
Methods: Sixty-two patients with SLE (40 steroid sensitive and 22 steroid resistant) and 21 normal controls were
recruited. Serum levels of MIF were measured by ELISA. Cytosolic MIF and IB expression in peripheral blood
mononuclear cells (PBMCs) were determined by western blotting. The electrophoretic mobility shift assay was assessed by
NF-B in nuclear aliquots. Gene silencing was applied to reduce expression of MIF in PBMCs in steroid-resistant patients.
PBMCs obtained from steroid-sensitive patients were treated with recombi
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