new neolignans and a phenylpropanoid glycoside from twigs of miliusa mollis新neolignans和树枝的phenylpropanoid糖苷miliusa mollis.pdfVIP

Molecules 2010, 15, 639-648; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article New Neolignans and a Phenylpropanoid Glycoside from Twigs of Miliusa mollis Kanokporn Sawasdee 1, Tanawat Chaowasku 2 and Kittisak Likhitwitayawuid 1,* 1 Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand; E-Mail: skanokporn7@ 2 Nationaal Herbarium Nederland, Leiden University, The Netherlands; E-Mail: chaowasku@nhn.leidenuniv.nl * Author to whom correspondence should be addressed; E-Mail: Kittisak.L@chula.ac.th; Tel.: +66-221-88-360 Fax: +66-221-88-357. Received: 8 December 2009; in revised form: 20 January 2010 / Accepted: 22 January 2010 / Published: 28 January 2010 Abstract: From the twigs of Miliusa mollis Pierre, three new compounds including (2S,3S)-2,3-dihydro-2-(4-methoxyphenyl)-3-methyl-5-[1(E)-propenyl]benzofuran, (7S,8S)- threo-Δ8′-4-methoxyneolignan and tyrosol-1-O-β-xylopyranosyl-(1→6)-O-β-gluco- pyranoside were isolated, along with seven known compounds. Their structures were elucidated through analysis of their spectroscopic data. Keywords: neolignan; phenylpropanoid glycoside; Miliusa mollis 1. Introduction The genus Miliusa Lesch. ex A.DC. (Annonaceae) comprises 30–40 species, which occur from India and South China to North Australia [1]. So far, there have been only a few reports on the constituents of plan