new insights into the protein c pathway potential implications for the biological activities of drotrecogin alfa (activated)新见解蛋白c通路潜在影响的生物活性drotrecogin阿尔法(激活).pdfVIP

下载本文档

1
0
约7万字
约 8页
2017-09-11 发布于上海
举报
版权申诉

new insights into the protein c pathway potential implications for the biological activities of drotrecogin alfa (activated)新见解蛋白c通路潜在影响的生物活性drotrecogin阿尔法(激活).pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

new insights into the protein c pathway potential implications for the biological activities of drotrecogin alfa (activated)新见解蛋白c通路潜在影响的生物活性drotrecogin阿尔法(激活)

Critical Care August 2005 Vol 9 Suppl 4 Macias et al. Review New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated) William L Macias, S Betty Yan, Mark D Williams, Suzane L Um, George E Sandusky, Darryl W Ballard and Jean-Michel S Planquois Lilly Research Laboratories, Indianapolis, Indiana, USA Corresponding author: Jean-Michel S Planquois, planquoisjs@ Published online: 25 August 2005 Critical Care 2005, 9(suppl 4):S38-S45 (DOI 10.1186/cc3747) This article is online at /supplements/9/S4/S38 © 2005 BioMed Central Ltd Abstract most instances, this results in a localized inflammatory and It has been hypothesized that the protein C pathway is a pivotal link procoagulant response that is beneficial in limiting spread of between the inflammation and coagulation cascades. The the infection, clearing pathogens, and aiding tissue healing demonstration that a survival benefit is associated with [3,4]. However, in a significant number of sepsis patients, administration of drotrecogin alfa (activated) (recombinant human activation of the immune system is poorly regulated, resulting activated protein C [APC]) in severe sepsis patients has provided in a systemic inflammatory and procoagulant response that is new insights into the protein C pathway. APC was originally frequently fatal [5,6]. Severe sepsis and septic shock