outcomes of highly active antiretroviral therapy in the context of universal access to healthcare the u.s. military hiv natural history study高活性抗逆转录病毒疗法的结果普遍获得医疗保健的上下文中美军艾滋病毒自然历史研究.pdfVIP

下载本文档

2
0
约7.29万字
约 10页
2017-09-11 发布于上海
举报
版权申诉

outcomes of highly active antiretroviral therapy in the context of universal access to healthcare the u.s. military hiv natural history study高活性抗逆转录病毒疗法的结果普遍获得医疗保健的上下文中美军艾滋病毒自然历史研究.pdf

1、本文档共10页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

outcomes of highly active antiretroviral therapy in the context of universal access to healthcare the u.s. military hiv natural history study高活性抗逆转录病毒疗法的结果普遍获得医疗保健的上下文中美军艾滋病毒自然历史研究

Marconi et al. AIDS Research and Therapy 2010, 7:14 /content/7/1/14 R E S E A R C H Open Access Research Outcomes of highly active antiretroviral therapy in the context of universal access to healthcare: the U.S. Military HIV Natural History Study Vincent C Marconi* 1,2,8, Greg A Grandits1,3, Amy C Weintrob1,4, Helen Chun1,5, Michael L Landrum1,2, Anuradha Ganesan1,6, Jason F Okulicz1,2, Nancy Crum-Cianflone1,4, Robert J OConnell1,7, Alan Lifson1,3, 1,4 1 Glenn W Wortmann , Brian K Agan* and the Infectious Disease Clinical Research Program HIV Working Group (IDCRP) Abstract Background: To examine the outcomes of highly-active antiretrov iral therapy (HAART) for individuals with free access to healthcare, we evaluated 2327 patients in a cohort study composed of military personnel and beneficiaries with HIV infection who initiated HAART from 1996 to the end of 2007. Methods: Outcomes analyzed were virologic suppression (VS) and failure (VF), CD4 count changes, AIDS and death. VF was defined as never suppressing or having at least one rebound event. Multivariate (MV) analyses stratified by the HAART initiation year (before or after 2000) were performed to identify risk factors associated with these outcomes. Results: Among patients who started HAART after 2000, 81% had VS at 1 year (N = 1,759), 85% at 5 years (N = 1,061), and 82% at 8 years (N = 735). Five years post-HAART, the median CD4 increase was 247 cells/ml and 34% experienced VF. AIDS and mortality rates at 5 years were 2% and 0.3%, respectively. In a MV model adjusted for known risk factors associated with treatment response, being on active duty (versus retired) at HAART initiation was associated with a decreased risk of AIDS (HR = 0.6, 95% CI 0.4-1.0) and mortality (0.6, 0.3-0.9), an increased pr