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perspectives and limitations of gene expression profiling in rheumatology new molecular strategies观点和基因表达分析的局限性在风湿病学新分子的策略.pdf

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perspectives and limitations of gene expression profiling in rheumatology new molecular strategies观点和基因表达分析的局限性在风湿病学新分子的策略

Arthritis Research Therapy Vol 6 No 4 Häupl et al. Commentary Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies 1 2 1 3 1 Thomas Häupl , Veit Krenn , Bruno Stuhlmüller , Andreas Radbruch and Gerd R Burmester 1Department of Rheumatology, Charité, Berlin, Germany 2Institute for Pathology, Charité, Berlin, Germany 3German Arthritis Research Centre (DRFZ), Berlin, Germany Corresponding author: Thomas Häupl, thomas.haeupl@charite.de Received: 13 Feb 2004 Revisions requested: 29 Mar 2004 Revisions received: 27 Apr 2004 Accepted: 12 May 2004 Published: 4 Jun 2004 Arthritis Res Ther 2004, 6:140-146 (DOI 10.1186/ar1194) © 2004 BioMed Central Ltd Abstract The deciphering of the sequence of the human genome has raised the expectation of unravelling the specific role of each gene in physiology and pathology. High-throughput technologies for gene expression profiling provide the first practical basis for applying this information. In rheumatology, with its many diseases of unknown pathogenesis and puzzling inflammatory aspects, these advances appear to promise a significant advance towards the identification of leading mechanisms of pathology. Expression patterns reflect the complexity of the molecular processes and are expected to provide the molecular basis for specific diagnosis, therapeutic stratification, long-term monitor