原创力文档phenotype-genotype analysis of cyp2c19 in colombian mestizo individualsphenotype-genotype cyp2c19在哥伦比亚混血儿个人分析.pdfVIP
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phenotype-genotype analysis of cyp2c19 in colombian mestizo individualsphenotype-genotype cyp2c19在哥伦比亚混血儿个人分析
BMC Clinical Pharmacology BioMed Central
Research article Open Access
Phenotype-genotype analysis of CYP2C19 in Colombian mestizo
individuals
1 1 2
Carlos Isaza* , Julieta Henao , José H Isaza Martínez , Juan C
1 1
Sepúlveda Arias and Leonardo Beltrán
Address: 1Grupo de Investigación en Farmacogenética, Universidad Tecnológica de Pereira, Facultad de Ciencias de la Salud, La Julita, Pereira,
Colombia, South America and 2Grupo Polifenoles UTP-CENIVAM, Facultad de Tecnología, Escuela de Química, Universidad Tecnológica de
Pereira, Pereira, Colombia, South America
Email: Carlos Isaza* - caisaza@.co; Julieta Henao - julietahenao@.co; José H Isaza Martínez - jhim@.co; Juan C
Sepúlveda Arias - jcsepulv@.co; Leonardo Beltrán - lbeltran@.co
* Corresponding author
Published: 11 July 2007 Received: 23 February 2007
Accepted: 11 July 2007
BMC Clinical Pharmacology 2007, 7:6 doi:10.1186/1472-6904-7-6
This article is available from: /1472-6904/7/6
© 2007 Isaza et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Omeprazole is metabolized by the hepatic cytochrome P450 (CYP) 2C19 enzyme
to 5-hydroxyomeprazole. CYP2C19 exhibits genetic polymorphisms responsible fo
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