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potent anti-hiv activities and mechanisms of action of a pine cone extract from pinus yunnanensis强有力的抗艾滋病活动的作用和机制松果从松属云南裂.pdf

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potent anti-hiv activities and mechanisms of action of a pine cone extract from pinus yunnanensis强有力的抗艾滋病活动的作用和机制松果从松属云南裂

Molecules 2012, 17, 6916-6929; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Potent Anti-HIV Activities and Mechanisms of Action of a Pine Cone Extract from Pinus yunnanensis Xuan Zhang 1,2,3,†, Liu-Meng Yang 1,†, Guang-Ming Liu 4, Ya-Juan Liu 1,3, Chang-Bo Zheng 5, Yong-Jun Lv 4, Hao-Zhi Li 4 and Yong-Tang Zheng 1,* 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Science Yunnan province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; E-Mails: snoopykm@126.com (X.Z.); lmyang@ (L.-M.Y.); liushui0703@126.com(Y.-J.L.) 2 School of Pharmaceutical Science, Kunming Medical University, Kunming 650500, China 3 Graduate School of the Chinese Academy of Science, Beijing 100039, China 4 School of Pharmacy, Dali University, Dali 671000, China; E-Mails: lgm888999@ (G.-M.L.); lvyongjun1939@126.com (Y.-J.L.); lihaozhi1943@126.com (H.-Z.L.) 5 School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China; E-Mail: normalbz@ † These authors contributed equally to the work. * Author to whom correspondence should be addressed; E-Mail: zhengyt@; Tel./Fax: +86-871-519-5684. Received: 5 April 2012; in revised form: 26 May 2012 / Accepted: 31 May 2012 / Published: 6 June 2012 Abstract: The anti-HIV activities of a pine cone extract (YNS-PY-F) from Pinus yunnanensis have been evaluated, and its mechanisms of action were also explored. The pine cone extract, YNS-PY-F, potently inhibited HIV-1IIIB, HIV-1RF, HIV-1A17, HIV-1AO18 and HIV-2ROD a