practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with cox-2 inhibitors and nsaids实用的方法来减少胃肠道和心血管安全问题与cox - 2抑制剂和非甾体抗炎药.pdfVIP

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practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with cox-2 inhibitors and nsaids实用的方法来减少胃肠道和心血管安全问题与cox - 2抑制剂和非甾体抗炎药.pdf

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practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with cox-2 inhibitors and nsaids实用的方法来减少胃肠道和心血管安全问题与cox - 2抑制剂和非甾体抗炎药

Available online /content/7/S4/S23 Review Practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with COX-2 inhibitors and NSAIDs James M Scheiman1 and A Mark Fendrick2 1Professor of Medicine in the Division of Gastroenterology at the University of Michigan Medical Center, Ann Arbor, Michigan, USA 2Professor of Internal Medicine and Health Management Policy at the University of Michigan Medical Center, Ann Arbor, Michigan, USA Corresponding author: James M Scheiman, jscheima@ Published: 15 September 2005 Arthritis Research Therapy 2005, 7(suppl 4):S23-S29 This article is online at /content/7/S4/S23 (DOI 10.1186/ar1795) © 2005 BioMed Central Ltd Abstract agents are associated with an increased risk for upper Nonsteroidal anti-inflammatory drugs (NSAIDs) are highly effective gastrointestinal toxicity, ranging from dyspepsia to gastro- in treating the pain and inflammation associated with osteoarthritis duodenal ulcers and bleeding. Although only a small and rheumatoid arthritis, but it is well recognized that these agents proportion of patients who use these agents develops gastro- are associated with substantial gastrointestinal toxicity. Treatment intestinal complications, the widespread use of these agents guidelines suggest that patients with one or more risk factors for magnifies the frequency into a large absolute number of NSAID associated ulcers should be prescribed preventive clinical gastrointestinal events. Individually and together, NSAID treatment. However, well over 80% of s