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quantification of signaling lipids by nano-electrospray ionization tandem mass spectrometry (nano-esi msms)量化的信号脂质nano-electrospray电离串联质谱(nano-esi男男同性恋者)
Metabolites 2012, 2, 57-76; doi:10.3390/metabo2010057
OPEN ACCESS
metabolites
ISSN 2218-1989
/journal/metabolites/
Article
Quantification of Signaling Lipids by Nano-Electrospray
Ionization Tandem Mass Spectrometry (Nano-ESI MS/MS)
Mathias Haag 1, Angelika Schmidt 2, Timo Sachsenheimer 1 and Britta Brügger 1,*
1 Heidelberg University Biochemistry Center, University of Heidelberg, Heidelberg, Germany;
E-Mails: mathias.haag@bzh.uni-heidelberg.de (M.H.);
timo.sachsenheimer@bzh.uni-heidelberg.de (T.S.)
2 Tumorimmunology Program, Division of Immunogenetics (D030), German Cancer Research
Center (DKFZ), Heidelberg, Germany; E-Mail: a.schmidt@dkfz.de
* Author to whom correspondence should be addressed;
E-Mail: britta.bruegger@bzh.uni-heidelberg.de; Tel.: +49-6221-54-5426; Fax: +49-6221-54-4366.
Received: 29 November 2011; in revised form: 4 January 2012 / Accepted: 6 January 2012 /
Published: 16 January 2012
Abstract: Lipids, such as phosphoinositides (PIPs) and diacylglycerol (DAG), are
important signaling intermediates involved in cellular processes such as T cell receptor
(TCR)-mediated signal transduction. Here we report identification and quantification of
PIP, PIP2 and DAG from crude lipid extracts. Capitalizing on the different extraction
properties of PIPs and DAGs allowed us to efficiently recover both lipid classes from one
sample. Rapid analysis of endogenous signaling molecules was performed by
nano-electrospray ionizatio
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