propofol neuroprotection in an in vitro model of traumatic brain injury异丙酚神经保护在创伤性脑损伤的体外模型.pdfVIP

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propofol neuroprotection in an in vitro model of traumatic brain injury异丙酚神经保护在创伤性脑损伤的体外模型.pdf

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propofol neuroprotection in an in vitro model of traumatic brain injury异丙酚神经保护在创伤性脑损伤的体外模型

Available online /content/13/2/R61 Vol 13 No 2 Open Access Research Propofol: neuroprotection in an in vitro model of traumatic brain injury 1 1 2 1 3 1 Jan Rossaint , Rolf Rossaint , Joachim Weis , Michael Fries , Steffen Rex and Mark Coburn 1Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany 2Institute of Neuropathology, University Hospital of the RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany 3Department of Surgical Intensive Care, University Hospital of the RWTH Aachen, Pauwelsstraße 30, 52074 Aachen, Germany Corresponding author: Mark Coburn, mcoburn@ukaachen.de Received: 26 Jan 2009 Revisions requested: 28 Feb 2009 Revisions received: 18 Mar 2009 Accepted: 27 Apr 2009 Published: 27 Apr 2009 Critical Care 2009, 13:R61 (doi:10.1186/cc7795) This article is online at: /content/13/2/R61 © 2009 Rossaint et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction The anaesthetic agent propofol (2,6- fluorescent only when it enters damaged cells via perforated cell diisopropylphenol) has been shown to be an effective membranes. Inside the cell, PI forms a fluorescent complex with neuroprotective agent in different in vitro models of brain injury nuclear DNA. induced by oxygen and glucose deprivation. We examined its