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recent advances in ocular drug delivery systems眼部给药系统的最新进展
Polymers 2011, 3, 193-221; doi:10.3390/polym3010193
OPEN ACCESS
polymers
ISSN 2073-4360
/journal/polymers
Review
Recent Advances in Ocular Drug Delivery Systems
Noriyuki Kuno * and Shinobu Fujii
Research and Development Center, Santen Pharmaceutical Co., Ltd., 8916-16 Takayama-cho,
Ikoma-shi, Nara 630-0101, Japan; E-Mail: shinobu.fujii.19@
* Author to whom correspondence should be addressed; E-Mail: noriyuki.kuno@;
Tel.: +81-743-79-4508; Fax: +81-743-79-4518.
Received: 2 November 2010; in revisedform: 9 December 2010 / Accepted: 31 December 2010 /
Published: 6 January 2011
Abstract: Transport of drugs applied by traditional dosage forms is restricted to the eye,
and therapeutic drug concentrations in the target tissues are not maintained for a long
duration since the eyes are protected by a unique anatomy and physiology. For the
treatment of the anterior segment of the eye, various droppable products to prolong the
retention time on the ocular surface have been introduced in the market. On the other hand,
direct intravitreal implants, using biodegradable or non-biodegradable polymer technology,
have been widely investigated for the treatment of chronic vitreoretinal diseases. There is
urgent need to develop ocular drug delivery systems which provide controlled release for
the treatment of chronic diseases, and increase patient ’s and doctor’s convenience to
reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug
delivery systems under clinical tria
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