原创力文档recent developments in the chemistry of deoxyribonucleic acid (dna) intercalators principles, design, synthesis, applications and trends最近的事态发展在脱氧核糖核酸(dna)的化学intercalators原则,设计、合成、应用和发展趋势.pdfVIP
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recent developments in the chemistry of deoxyribonucleic acid (dna) intercalators principles, design, synthesis, applications and trends最近的事态发展在脱氧核糖核酸(dna)的化学intercalators原则,设计、合成、应用和发展趋势
Molecules 2009, 14, 1725-1746; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Review
Recent Developments in the Chemistry of Deoxyribonucleic
Acid (DNA) Intercalators: Principles, Design, Synthesis,
Applications and Trends
Brenno A. D. Neto 1,* and Alexandre A. M. Lapis 2
1 Laboratory of Medicinal and Technological Chemistry, University of Brasilia (IQ-UnB), Brasilia,
DF, Brazil
2 Universidade Federal do Pampa, Unipampa, Bagé, RS, Brazil
* Author to whom correspondence should be addressed; E-mail: brenno.ipi@.
Received: 15 February 2009; in revised form: 20 April 2009 / Accepted: 5 May 2009 /
Published: 7 May 2009
Abstract: In the present overview, we describe the bases of intercalation of small
molecules (cationic and polar neutral compounds) in DNA. We briefly describe the
importance of DNA structure and principles of intercalation. Selected syntheses,
possibilities and applications are shown to exemplify the importance, drawbacks and
challenges in this pertinent, new, and exciting research area. Additionally, some clinical
applications (molecular processes, cancer therapy and others) and trends are described.
Keywords: DNA; RNA; photointercalators; fluorescence; rational design; therapy; cancer
1. Introduction
DNA is a nucleic acid (biomolecule) that contains the genetic instructions specifying the biological
development of all cellular forms of life (and many viruses). DNA is often referred to as the molecule
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