原创力文档reflex, a social-cognitive group treatment to improve insight in schizophrenia study protocol of a multi-center rct反射,社会认知组治疗改善精神分裂症的见解多中心个随机对照试验的研究方案.pdfVIP
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reflex, a social-cognitive group treatment to improve insight in schizophrenia study protocol of a multi-center rct反射,社会认知组治疗改善精神分裂症的见解多中心个随机对照试验的研究方案
Pijnenborg et al. BMC Psychiatry 2011, 11:161
/1471-244X/11/161
STUDY PROTOCOL Open Access
REFLEX, a social-cognitive group treatment to
improve insight in schizophrenia: study protocol
of a multi-center RCT
1,2,4* 5,6 2 3,4 2,4
GHM Pijnenborg , Mark Van der Gaag , Claudi LH Bockting , Lisette Van der Meer and André Aleman
Abstract
Background: Insight is impaired in a majority of people with schizophrenia. Impaired insight is associated with
poorer outcomes of the disorder. Based on existing literature, we developed a model that explains which
processes may possibly play a role in impaired insight. This model was the starting point of the development of
REFLEX: a brief psychosocial intervention to improve insight in schizophrenia. REFLEX is a 12-sessions group
training, consisting of three modules of four sessions each. Modules in this intervention are: “coping with stigma”,
“you and your personal narrative”, and “you in the present”.
Methods/Design: REFLEX is currently evaluated in a multicenter randomized controlled trial. Eight mental health
institutions in the Netherlands participate in this evaluation. Patients are randomly assigned to either REFLEX or an
active control condition, existing of cognitive remediation exercises in a group. In a subgroup of patients, fMRI
scans are made before and after training in order to assess potential haemodynamic changes associated with the
effects of the training.
Discussion: REFLEX is one of the few interventions aiming specifically to improving insight in schizophrenia and
has potential value for improving insight. Targeting insight in schizophrenia is a complex task, that comes with
several methodological issues.
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