原创力文档regulation of fission yeast morphogenesis by pp2a activator pta2裂殖酵母的监管由pp2a活化剂pta2形态发生.pdfVIP
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regulation of fission yeast morphogenesis by pp2a activator pta2裂殖酵母的监管由pp2a活化剂pta2形态发生
Regulation of Fission Yeast Morphogenesis by PP2A
Activator pta2
Manuel Bernal, Maria Antonia Sanchez-Romero, Silvia Salas-Pino, Rafael R. Daga*
´ ´
Centro Andaluz de Biologıa del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Cientıficas, Junta de Andalucia, Sevilla, Spain
Abstract
Cell polarization is key for the function of most eukaryotic cells, and regulates cell shape, migration and tissue architecture.
Fission yeast, Schizosaccharomyces pombe cells are cylindrical and polarize cell growth to one or both cell tips dependent on
the cell cycle stage. Whereas microtubule cytoskeleton contributes to the positioning of the growth sites by delivering
polarity factors to the cell ends, the Cdc42 GTPase polarizes secretion via actin-dependent delivery and tethering of
secretory vesicles to plasma membrane. How growth is restricted to cell tips and how re-initiation of tip growth is regulated
in the cell cycle remains poorly understood. In this work we investigated the function of protein phosphatase type 2A
(PP2A) in S. pombe morphogenesis by deleting the evolutionary conserved PTPA-type regulatory subunit that we named
pta2. pta2-deleted cells showed morphological defects and altered growth pattern. Consistent with this, actin patches and
active Cdc42 were mislocalized in the pta2 deletion. These defects were additive to the lack of Cdc42-GAP Rga4. pta2D cells
show upregulated Cdc42 activity and pta2 interacts genetically with polarisome components Tea1, Tea4 and For3 leading to
complete loss of cell polarity and rounded morphology. Thus, regulation of polarity by PP2A requires the polarisome and
involves Pta2-dependent control of Cdc42 activity.
Citation: Bernal M, Sanchez-Rome
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