原创力文档recent developments in anti-rheumatic drugs in pediatrics treatment of juvenile idiopathic arthritis最近的事态发展在儿科治疗青少年特发性关节炎风湿性关节炎药物.pdfVIP
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recent developments in anti-rheumatic drugs in pediatrics treatment of juvenile idiopathic arthritis最近的事态发展在儿科治疗青少年特发性关节炎风湿性关节炎药物
Available online /content/11/1/216
Review
Recent developments in anti-rheumatic drugs in pediatrics:
treatment of juvenile idiopathic arthritis
Kristen Hayward and Carol A Wallace
Division of Rheumatology, University of Washington School of Medicine, Seattle Children’s Hospital, 4800 Sandpoint Way, NE MS R-5420, Seattle,
WA 98105, USA
Corresponding author: Carol A Wallace, cwallace@
Published: 23 February 2009 Arthritis Research Therapy 2009, 11:216 (doi:10.1186/ar2619)
This article is online at /content/11/1/216
© 2009 BioMed Central Ltd
Abstract chronic uveitis associated with JIA) [3,4]. In the case of the
Juvenile idiopathic arthritis (JIA) is the most common autoimmune– systemic-onset form of JIA (SOJIA), untreated disease may
autoinflammatory disease in childhood and affects approximately even result in multiple organ failure and death.
1 in 1,000 children. Despite advances in diagnosis and treatment
options, JIA remains a chronic condition for most affected children. Twenty years ago it was commonly believed that childhood-
Recent evidence suggests that disease control at onset may onset arthritis might subside in adulthood. Recent studies,
determine the tempo of subsequent disease course and long-term
however, have demonstrated that sustained resolution of
outcomes, and raises the concept of a therapeutic window of
opportunity in patients with JIA. This underscores the importance of disease occurs in only a small minority of JIA patients (as
early aggressive treatment in pat
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