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quality of life is predictive of relapse in schizophrenia生活质量是在精神分裂症复发的预测
Boyer et al. BMC Psychiatry 2013, 13:15
/1471-244X/13/15
RESEARCH ARTICLE Open Access
Quality of life is predictive of relapse in
schizophrenia
1* 2 2 2 1 3
Laurent Boyer , Aurelie Millier , Emeline Perthame , Samuel Aballea , Pascal Auquier and Mondher Toumi
Abstract
Background: The objective of this study was to evaluate whether quality of life (QoL), as measured by the SF36
and the Quality of Life Interview (QoLI), is predictive of relapse for patients with schizophrenia.
Methods: Using data from a multicenter cohort study conducted in France, Germany, and the United-Kingdom
(EuroSC), we performed Cox proportional-hazards models to estimate the associations between QoL at baseline
and the occurrence of relapse over a 24-month period, with adjustment for age; gender; positive, negative and
general psychopathology PANSS factors; functioning (GAF); medication; side-effects; and compliance measures.
Results: Our sample consisted of 1,024 patients; 540 (53%) had at least one period of relapse, and 484 (47%) had
no relapse. QoL levels were the most important features predicting relapse. We found that a higher level of QoL
predicts a lower rate of relapse at 24 months: HR = 0.82 (0.74; 0.91), p 0.001 for the SF36-Physical Composite Score;
and HR = 0.88 (0.81; 0.96), p = 0.002 for the SF36-Mental Composite Score. These results were not confirmed using
the QoLI: HR = 0.91 (0.81; 1.01), p = 0.083. To a lesser extent, older age, better functioning, and a higher compliance
score also predict a lower rate of relapse at 24 months (HRs from 0.97 to 0.98; p 0.05).
Conclusions: QoL, as assessed by the SF36, is an independent predictor of relapse at a 24-month follow-up in
sc
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