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risk factors for ana positivity in healthy persons安娜的危险因素积极健康的人
Li et al. Arthritis Research Therapy 2011, 13:R38
/content/13/2/R38
RESEARCH ARTICLE Open Access
Risk factors for ANA positivity in healthy persons
1* 2 2 2 1 1 3
Quan-Zhen Li , David R Karp , Jiexia Quan , Valerie K Branch , Jinchun Zhou , Yun Lian , Benjamin F Chong ,
Edward K Wakeland1 and Nancy J Olsen2,4*
Abstract
Introduction: The finding of antinuclear antibody (ANA) positivity in a healthy individual is usually of unknown
significance and in most cases is benign. However, a subset of such individuals is at risk for development of
autoimmune disease. We examined demographic and immunological features that are associated with ANA
positivity in clinically healthy persons to develop insights into when this marker carries risk of progression to lupus.
Methods: Biological samples from healthy individuals and patients with systemic lupus erythematosus (SLE) were
obtained from the Dallas Regional Autoimmune Disease Registry (DRADR). Measurements carried out on serum
samples included ANA, extractable nuclear antibodies (ENA) and autoantibody profiling using an array with more
than 100 specificities. Whole blood RNA samples from a subset of individuals were used to analyze gene
expression on the Illumina platform. Data were analyzed for associations of high ANA levels with demographic
features, the presence of other autoantibodies and with gene expression profiles.
Results: Overall, ANA levels are significantly higher in females than in males and this association holds in patients
with the autoimmune diseases lupus and rheumatoid arthritis (RA) as well as in healthy controls (HC). Age was not
significantly associated with ANA levels and the elevated ANA values could not be explained
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