原创力文档risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (soho) study自杀行为的危险因素在观察精神分裂症门诊健康结果(soho)研究.pdfVIP
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risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (soho) study自杀行为的危险因素在观察精神分裂症门诊健康结果(soho)研究
Brugnoli et al. BMC Psychiatry 2012, 12:83
/1471-244X/12/83
RESEARCH ARTICLE Open Access
Risk factors for suicide behaviors in the
observational schizophrenia outpatient health
outcomes (SOHO) study
1 2 3 4 5 4
Roberto Brugnoli , Diego Novick , Josep Maria Haro , Andrea Rossi , Marco Bortolomasi , Sonia Frediani and
Giuseppe Borgherini6,7*
Abstract
Background: To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of
schizophrenia (SOHO study).
Methods: Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression
post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who
did not.
Results: 384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant
risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events,
male gender and history of hospitalization for schizophrenia.
Conclusions: In view of the observational design of the study and the post-hoc nature of the analysis, the
identified risk factors should be confirmed by ad-hoc specifically designed studies.
Keywords: Suicide, Schizophrenia, Observational study
Background A major hurdle in the prevention of suicide in schizo-
One of the most important causes of death among phrenia is the difficulty in evaluating the risk of suicidal
patients with schizophrenia is suicide [1]. It has been behaviors, as suicide in this patient population usually is
established that the risk
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