role of cox-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndromecox - 2在咳嗽反射敏感性在sinobronchial综合症患者吸入辣椒素.pdfVIP

Ishiura et al. Cough 2010, 6:7 /content/6/1/7 Cough RESEARCH Open Access Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome 1* 2 1 2 2 Yoshihisa Ishiura , Masaki Fujimura , Hiroki Yamamoto , Noriyuki Ohkura , Shigeharu Myou Abstract Background: Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation. Methods: The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity. Results: The cough threshold was significantly (p 0.03) increased after two-week treatment with etodolac (200 mg twice a day orally) compared with placebo [37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) μM]. Conclusions: These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome. Background sinobronchial syndrome, however, exact mec