原创力文档roles of probiotics and prebiotics in colon cancer prevention postulated mechanisms and in-vivo evidence益生菌和益生元的角色在结肠癌预防假设机制和体内的证据.pdfVIP
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roles of probiotics and prebiotics in colon cancer prevention postulated mechanisms and in-vivo evidence益生菌和益生元的角色在结肠癌预防假设机制和体内的证据
Int. J. Mol. Sci. 2008, 9, 854-863; DOI: 10.3390/ijms9050854
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/ijms
Review
Roles of Probiotics and Prebiotics in Colon Cancer Prevention:
Postulated Mechanisms and In-vivo Evidence
Min-Tze Liong
Food Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Minden,
Penang, Malaysia; E-mail: mintze.liong@usm.my; Tel-: +604-653-2114; Fax: +604-657-3678
Received: 19 March 2008; in revised form: 15 May 2008 / Accepted: 16 May 2008 /
Published: 20 May 2008
Abstract: Probiotics are live bacteria that could exert health beneficial effects upon
consumption. In additional to their conventional use as gut modulators, probiotics are
investigated for their role to prevent cancer. In-vivo and molecular studies have
demonstrated encouraging outcomes, mainly attributed to its antimicrobial effects against
carcinogen-producing microorganisms, antimutagenic properties, and alteration of the tumor
differentiation processes. Prebiotics are indigestible food components that could promote
the growth of beneficial bacteria including probiotics. Present studies have suggested that
prebiotics also possess protective effect against colon carcinogenesis, mainly attributed to
the production of short chain fatty acids upon its fermentation
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