salvianolic acid a inhibits pdgf-bb induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesissalvianolic酸抑制pdgf-bb诱导血管平滑肌细胞迁移和增殖而不抑制内皮细胞增殖和一氧化氮生物合成.pdfVIP

Molecules 2012, 17, 3333-3347; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Salvianolic Acid A Inhibits PDGF-BB Induced Vascular Smooth Muscle Cell Migration and Proliferation While Does Not Constrain Endothelial Cell Proliferation and Nitric Oxide Biosynthesis Lan Sun, Rui Zhao, Li Zhang, Tiantai Zhang, Wenyu Xin, Xi Lan, Chao Huang and Guanhua Du * Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China * Author to whom correspondence should be addressed; E-Mail: dugh@; Tel./Fax: +86-10-6316-5184. Received: 31 January 2012; in revised form: 3 March 2012 / Accepted: 6 March 2012 / Published: 14 March 2012 Abstract: Proliferation and migration of vascular smooth muscle cells (VSMCs) are critical events in the initiation and development of restenosis upon percutaneous transluminal coronary angioplasty (PTCA). Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Salvianolic A (SalA) is one of the most abundant polyphenols extracted from salvia. In this study, we investigated the effect of salvianolic A (SalA) on the migration and proliferation of VSMCs. We found a preferential interaction of SalA with cellular systems that rely on the PDGF signal, but not on the EGF and bFGF signal. SalA inhibits PDGF-BB induced VSMC proliferation and migration in the concentration range from 0.01 to 0.1 μM. The inhibitio