scaling dynamic response and destructive metabolism in an immunosurveillant anti-tumor system modulated by different external periodic interventions扩展动态响应和破坏性的新陈代谢immunosurveillant抗肿瘤由不同的外部系统调制周期干预措施.pdfVIP

Scaling Dynamic Response and Destructive Metabolism in an Immunosurveillant Anti-Tumor System Modulated by Different External Periodic Interventions 1 1 2 3 Yuanzhi Shao *, Wenyong Hu , Weirong Zhong , Li Li 1 School of Physics and Engineering, Department of Physics, Sun Yat-sen University, Guangzhou, China, 2 Department of Physics, Jinan University, Guangzhou, China, 3 State Key Laboratory of Oncology in Southern China, Sun Yat-sen University, Guangzhou, China Abstract On the basis of two universal power-law scaling laws, i.e. the scaling dynamic hysteresis in physics and the allometric scaling metabolism in biosystem, we studied the dynamic response and the evolution of an immunosurveillant anti-tumor system subjected to a periodic external intervention, which is equivalent to the scheme of a radiotherapy or chemotherapy, within the framework of the growth dynamics of tumor. Under the modulation of either an abrupt or a gradual change external intervention, the population density of tumors exhibits a dynamic hysteresis to the intervention. The area of dynamic hysteresis loop characterizes a sort of dissipative-therapeutic relationship of the dynamic responding of treated tumors with the dose consumption of accumulated external intervention per cycle of therapy. Scaling the area of dynamic hysteresis loops against the intensity of an external intervention, we deduced a characteristic quantity which was defined as the theoretical therapeutic effectiveness of treated tumor and related with the destructive metabolism of tumor under treatment. The calculated dose-effectiveness profiles, namely the dose cumulant per cycle of intervention versus the therapeutic effectiveness, could be well scaled into a universal quadratic formula