role of cell division autoantigen 1 (cda1) in cell proliferation and fibrosis细胞分裂的角色自身抗原1(cda1)在细胞增殖和纤维化.pdfVIP

Genes 2010, 1, 335-348; doi:10.3390/genes1030335 OPEN ACCESS genes ISSN 2073-4425 /journal/genes Review Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis Ban-Hock Toh 1,*, Yugang Tu 2, Zemin Cao 2, Mark E. Cooper 2 and Zhonglin Chai 2 1 Autoimmunity Laboratory, Centre for Inflammatory Diseases, Department of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3168, Australia 2 Diabetes and Metabolism Division, Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria 3004, Australia; E-Mails: Yugang.Tu@.au (Y.T.); Zemin.Cao@.au (Z.C.); Mark.Cooper@.au (M.E.C.); Zhonglin.Chai@.au (Z.C.) * Author to whom correspondence should be addressed; E-Mail: Ban-Hock.Toh@; Tel.: +61-3 Fax: +61-3 Received: 5 August 2010; in revised form: 3 September 2010 / Accepted: 17 September 2010 / Published: 30 September 2010 Abstract: Cell Division Autoantigen 1 (CDA1) was discovered following screening a human expression library with serum from a patient with Discoid Lupus Erythematosus. CDA1, encoded by TSPYL2 on the X chromosome, shares anti-proliferative and pro-fibrotic properties with TGF- It inhibits cell growth through p53, pERK1/2 and p21-mediated pathways and is implicated in tumorigenesis and the DNA damage response. Its pro-fibrotic property is mediated through cross-talk with TGF- that results in upregulation of extracel