role of acetyl-phosphate in activation of the rrp2-rpon-rpos pathway in borrelia burgdorferi乙酰磷酸在rrp2-rpon-rpos通路的活化中的作用。伯氏疏螺旋体.pdfVIP

Role of Acetyl-Phosphate in Activation of the Rrp2-RpoN-RpoS Pathway in Borrelia burgdorferi 1,2 3 4 2 3,4 5 Haijun Xu , Melissa J. Caimano , Tao Lin , Ming He , Justin D. Radolf , Steven J. Norris , Frank 6 7 2 Gheradini , Alan J. Wolfe , X. Frank Yang * 1 Institute of Insect Science, Zhejiang University, Hangzhou, China, 2 Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 3 Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, United States of America, 4 Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America, 5 Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, Texas, United States of America, 6 National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana, United States of America, 7 Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, United States of America Abstract Borrelia burgdorferi, the Lyme disease spirochete, dramatically alters its transcriptome and proteome as it cycles between the arthropod vector and mammalian host. During this enzootic cycle, a novel regulatory network, the Rrp2-RpoN-RpoS pathway (also known as the s54–sS sigma factor cascade), plays a central role in modulating the differential expression of more than 10% of all B. burgdorferi genes, including the major virulence genes ospA and ospC. However, the mechanism(s) by which the upstream activator and response regulator Rrp2 is activated remains unc