role of abo secretor status in mucosal innate immunity and h. pylori infectionabo血型在粘膜分泌腺地位角色先天免疫和幽门螺旋杆菌感染.pdfVIP

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role of abo secretor status in mucosal innate immunity and h. pylori infectionabo血型在粘膜分泌腺地位角色先天免疫和幽门螺旋杆菌感染.pdf

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role of abo secretor status in mucosal innate immunity and h. pylori infectionabo血型在粘膜分泌腺地位角色先天免疫和幽门螺旋杆菌感染

Role of ABO Secretor Status in Mucosal Innate Immunity and H. pylori Infection ´ 1,2,3 4 1,2 5 6 ´ 7* Sara Linden , Jafar Mahdavi , Cristina Semino-Mora , Cara Olsen , Ingemar Carlstedt , Thomas Boren , Andre Dubois1,2* 1 Laboratory of Gastrointestinal and Liver Studies, Digestive Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, 2 United States Military Cancer Institute, Bethesda, Maryland, United States of America, 3 Mucosal Diseases Program, Mater Medical Research Institute, South Brisbane, Australia, 4 Division of Microbiology and Infectious Diseases, Queen’s Medical Centre, Nottingham, United Kingdom, 5 Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, 6 Mucosal Biology Group, Department of Cell- and Molecular Biology, BMC, Lund University, Lund, Sweden, 7 Department of Medical Biochemistry and Biophysics, and Laboratory for Molecular ˚ ˚ Infection Medicine Sweden (MIMS), Umea University, Umea, Sweden The fucosylated ABH antigens, which constitute the molecular basis for the ABO blood group system, are also expressed in salivary secretions and gastrointestinal epithelia in individuals of positive secretor status; however, the biological function of the ABO blood group system is unknown. Gastric mucosa biopsies of 41 Rhesus monkeys originating from Southern Asia were analyzed by immunohistochemistry. A majority of these animals were found to be of blood group