role of basal ganglia circuits in resisting interference by distracters a swloreta study基底神经节的作用在抗干扰电路错误swloreta研究.pdfVIP

Role of Basal Ganglia Circuits in Resisting Interference by Distracters: A swLORETA Study 1,2,3 2,3 4 ´ 1,5 Perrine Bocquillon *, Jean-Louis Bourriez , Ernesto Palmero-Soler , Alain Destee , Luc Defebvre1,2,5, Philippe Derambure1,2,3, Kathy Dujardin1,2,5 1 University of Lille Nord de France, Lille, France, 2 Lab. Neurosciences Fonctionnelles et Pathologies, Lille, France, 3 Clinical Neurophysiology Department, Lille University Medical Center, Lille, France, 4 Eemagine Medical Imaging Solutions GmbH, Berlin, Germany, 5 Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France Abstract Background: The selection of task-relevant information requires both the focalization of attention on the task and resistance to interference from irrelevant stimuli. Both mechanisms rely on a dorsal frontoparietal network, while focalization additionally involves a ventral frontoparietal network. The role of subcortical structures in attention is less clear, despite the fact that the striatum interacts significantly with the frontal cortex via frontostriatal loops. One means of investigating the basal ganglia’s contributions to attention is to examine the features of P300 components (i.e. amplitude, latency, and generators) in patients with basal ganglia damage (such as in Parkinson’s disease (PD), in which attention is often impaired). Three-stimulus oddball paradigms can be used to study distracter-elicited and target-elicited P300 subcomponents. Methodology/Principal Findings: In order to compare distracter- and target-elicited P300 components, high-density (128- ch