role of cd14 in lung inflammation and infectioncd14在肺部炎症和感染的作用.pdfVIP

Anas et al. Critical Care 2010, 14:209 /content/14/2/209 R E V I E W Role of CD14 in lung inl ammation and infection Adam Anas, Tom van der Poll, and Alex F de Vos* This article is one of ten reviews selected from the Yearbook of Intensive Care and Emergency Medicine 2010 (Springer Verlag) and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum/series/yearbook. Further information about the Yearbook of Intensive Care and Emergency Medicine is available from /series/2855. Introduction h e protein was fi rst identifi ed as a diff erentiation marker Toll-like receptors (TLR) on the surface of cells of the on the surface of monocytes and macrophages and was respiratory tract play an essential role in sensing the designated CD14 at the fi rst leukocyte typing workshop presence of microorganisms in the airways and lungs. in Paris in 1982. h e genomic DNA of human CD14 was h ese receptors trigger infl ammatory responses, activate cloned in 1988 and the gene was later mapped to innate immune responses, and prime adaptive immune chromo some 5q23–31. Several polymorphisms have responses to eradicate invading microbes [1]. TLR are been found in the CD14 gene, of which nucleotide poly- members of a family of pattern-recognition receptors, morphisms at position –159 and –1619 correlated with which recognize molecular structures of bacteria, viruses, decreased lung function in endotoxin-exposed farmers [3]. fungi and protozoa (pathogen-associated molecular h e CD14 gene consists of two exons which code for a pattern