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screening of crude plant extracts with anti-obesity activity筛选天然植物提取物的抗肥胖活动
Int. J. Mol. Sci. 2012, 13, 1710-1719; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Screening of Crude Plant Extracts with Anti-Obesity Activity
Changhyun Roh * and Uhee Jung *
Radiation Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI),
Korea Atomic Energy Research Institute (KAERI), 1266, Shinjeong-dong, Jeongeup,
Jeonbuk 580-185, Korea
* Authors to whom correspondence should be addressed; E-Mails: chroh@kaeri.re.kr (C.R.);
uhjung@kaeri.re.kr (U.J.); Tel.: +82-63-570-3227 (C.R.); Fax: +82-63-570-3229 (C.R.);
Tel.: +82-63-570-3221 (U.J.); Fax: +82-63-570-3229 (U.J.).
Received: 15 November 2011; in revised form: 20 December 2011 / Accepted: 17 January 2012 /
Published: 6 February 2012
Abstract: Obesity is a global health problem. It is also known to be a risk factor for the
development of metabolic disorders, type 2 diabetes, systemic hypertension, cardiovascular
disease, dyslipidemia, and atherosclerosis. In this study, we screened crude extracts from
400 plants to test their anti-obesity activity using porcine pancreatic lipase assay (PPL;
triacylglycerol lipase, EC ) in vitro activity. Among the 400 plants species examined,
44 extracts from plants, showed high anti-lipase activity using 2,4-dinitrophenylbutyrate as
a substrate in porcine pancreatic lipase assay. Furthermore, 44 plant extracts
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