sedentary subjects have higher pai-1 and lipoproteins levels than highly trained athletes久坐不动的主题pai-1和脂蛋白水平高于训练有素的运动员.pdfVIP

Lira et al. Diabetology Metabolic Syndrome 2010, 2:7 /content/2/1/7 RESEARCH Open Access Sedentary subjects have higher PAI-1 and lipoproteins levels than highly trained athletes 1* 1 2 3 3 3 Fabio S Lira , Jose C Rosa , Adriano E Lima-Silva , Hélio A Souza , Erico C Caperuto , Marília C Seelaender , 4 4 4* Ana R Damaso , Lila M Oyama , Ronaldo VT Santos Abstract Physical exercise protects against the development of cardiovascular disease, partly by lowering plasmatic total cholesterol, LDL-cholesterol and increased HDL-cholesterol levels. In addition, it is now established that reduction plasmatic adiponectin and increased C-reactive protein (CRP) and plasminogen activator inhibitor-1 (PAI-1) levels play a role in the maintenance of an inflammatory state and in the development of cardiovascular disease. This study aimed to examine plasma lipid profile and inflammatory markers levels in individual with sedentary lifestyle and/or highly trained athletes at rest. Methods: Fourteen male subjects (sedentary lifestyle n = 7 and highly trained athletes n = 7) were recruited. Blood samples were collected after an overnight fast (~12 h). The plasmatic lipid profile (Triglycerides, HDL-cholesterol, LDL-cholesterol, total cholesterol, LDL-oxidized and total cholesterol/HDL-c ratio), glucose, adiponectin, C - reactive protein and PAI-1 levels were determined. Results: Total cholesterol, LDL- cholesterol, TG and PAI-1 levels were lower in highly trained athletes group in relation to sedentary subjects (p 0.01). In addition, we observed a positive correlation between PAI-1 and total cholesterol (r = 0.78; p 0.0009), PAI- 1 and LDL-c (r