scaling behavior of human locomotor activity amplitude association with bipolar disorder扩展人类行为的运动活动振幅与双相情感障碍.pdfVIP

Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder 1 2,3,4 4 4,5 4 Premananda Indic *, Paola Salvatore , Carlo Maggini , Stefano Ghidini , Gabriella Ferraro , Ross J. Baldessarini2,3, Greg Murray6 1 Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 2 Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America, 3 International Consortium for Psychotic and Bipolar Disorders Research, McLean Hospital, Belmont, Massachusetts, United States of America, 4 Section of Psychiatry, Department of Neuroscience, University of Parma, Parma, Italy, 5 Forensic Hospital, Mental Health Department of Reggio Emilia, Reggio Emilia, Italy, 6 Faculty of Life and Social Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia Abstract Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at h