sedation improves early outcome in severely septic sprague dawley rats镇静改善早期结果严重感染性的雄性sd大鼠中.pdfVIP

Available online /content/13/4/R136 Vol 13 No 4 Open Access Research Sedation improves early outcome in severely septic Sprague Dawley rats 1 2 2 1 2 Hong Qiao , Robert D Sanders , Daqing Ma , Xinmin Wu and Mervyn Maze 1Department of Anesthesiology, First Hospital, Peking University, No. 8 Xishiku St., Beijing 100034, PR China 2Department of Anaesthetics, Intensive Care and Pain Medicine, Imperial College London, Chelsea Westminster Hospital, 369 Fulham Rd, London, SW10 9NH, UK Corresponding author: Robert D Sanders, robert.sanders@imperial.ac.ukXinmin Wu, xmwu2784@ Received: 20 May 2009 Revisions requested: 7 Jul 2009 Revisions received: 14 Jul 2009 Accepted: 19 Aug 2009 Published: 19 Aug 2009 Critical Care 2009, 13:R136 (doi:10.1186/cc8012) This article is online at: /content/13/4/R136 © 2009 Qiao et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Sepsis, a systemic inflammatory response to addition, spleens were harvested and apoptosis was assessed infective etiologies, has a high mortality rate that is linked both by immunoblotting (n = 4 per group). to excess cytokine activity and apoptosis of critical immune Results The 24 hour MR in CLIP animals (90%) was cells. Dexmedetomidine has