原创力文档selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus选择性胆碱能消耗在内侧隔导致受损长期势差现象和glutamatergic海马的突触电流.pdfVIP
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selective cholinergic depletion in medial septum leads to impaired long term potentiation and glutamatergic synaptic currents in the hippocampus选择性胆碱能消耗在内侧隔导致受损长期势差现象和glutamatergic海马的突触电流
Selective Cholinergic Depletion in Medial Septum Leads
to Impaired Long Term Potentiation and Glutamatergic
Synaptic Currents in the Hippocampus
Patrick M. Kanju1,2., Kodeeswaran Parameshwaran1,3., Catrina Sims-Robinson1,4, Subramaniam
1,5 6 7 1
Uthayathas , Eleanor M. Josephson , Nagalingam Rajakumar , Muralikrishnan Dhanasekaran , Vishnu
Suppiramaniam1*
1 Department of Pharmacal Sciences, Auburn University, Auburn, Alabama, United States of America, 2 Department of Neurobiology, Duke University Medical Center,
Durham, North Carolina, United States of America, 3 Department of Pathobiology, Auburn University, Auburn, Alabama, United States of America, 4 Department of
Neurology, University of Michigan, Ann Arbor, Michigan, United States of America, 5 Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia,
United States of America, 6 Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, Alabama, United States of America, 7 Department of
Anatomy and Cell Biology, The University of Western Ontario, London, Ontario, Canada
Abstract
Cholinergic depletion in the medial septum (MS) is associated with impaired hippocampal-dependent learning and
memory. Here we investigated whether long term potentiation (LTP) and synaptic currents, mediated by alpha-amino-3-
hydroxy-5-methyl-isoxazole-4-propionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors in the CA1 hippocampal
region, are affected following cholinergic lesions of the MS. Stereotaxic intra-medioseptal infusions of a selective
immunotoxin, 192-saporin, against cholinergic neurons or sterile saline were made in adult rats. Four days after infusions,
hippocampal slic
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